Jason Isbell and Amanda Shires will team up for a duet concert on December 12th at the Columbia Speedway Entertainment Center in Cayce, South Carolina, the couple announced on Tuesday. Earlier this month, Isbell and his wife/400 Unit bandmate put on a series of three concerts throughout the Carolinas as well as kicked off the Live From The Drive In series at Ameris Bank Amphitheatre in Alpharetta, GA back on October 16th.Related: Amanda Shires, Jason Isbell Go Live For Grimey’s New & Preloved Music [Watch]Much like their previous duo performances—both live and for the I So Lounging streaming series—the concert will see both talented musicians exploring one another’s expansive songbooks. From Isbell and Shires’ respective solo catalogs through their work together as Jason Isbell & The 400 Unit—including their new album Reunions—everything is on the table, including choice covers.Tickets for Jason Isbell and Amanda Shires at the Columbia Speedway Entertainment Center in South Carolina go on sale at 10 a.m. ET on Thursday, November 19th. The tickets are available for groups no larger than four, and will reportedly range from $180 to $260, according to venue officials. Click here for more information.The couple recently made headlines following last week’s Country Music Association (CMA) Awards. Isbell and Shires joined in with other prominent country musicians including Sturgill Simpson in calling out the Association’s blatant disregard for John Prine, as well as recently-deceased outlaw country legends Jerry Jeff Walker and Billy Joe Shaver, during the award ceremony. Shires and Isbell even went a step further and have returned their memberships to the governing body.[H/T The State]
Share Share on Facebook Researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden might be one step closer to finding an effective drug for alcohol dependence. In two separate studies, they show that the dopamine stabilizer OSU6162 can reduce the craving for alcohol in alcohol dependent people and normalises the level of dopamine in the brain reward system of rats that have consumed alcohol over a long period of time. However, thorough clinical studies are needed to determine if the OSU6162 also can help alcohol dependent people drink less alcohol. Share on Twitter LinkedIn Pinterest “The results of our studies are promising, but there is still a long way to go before we have a marketable drug,” says Pia Steensland, Associate Professor at the Department of Clinical Neuroscience, Karolinska Institutet and co-author of both studies. “The socioeconomic costs of alcohol are huge, not to mention the human suffering. It is inspiring to continue working.”Roughly a million Swedes over 15 years of age drink so much alcohol that they risk damaging their health, and it is estimated that some 300,000 of these people are dependent. Despite the pressing need, there are only a few approved drugs for the treatment of alcohol dependence, but their effects vary from person to person and the prescriptions rates are low. Consequently the hunt for new, more efficacious drugs for alcohol dependence continues. Email Clinical studyThe studies of OSU6162 are based on the knowledge of how the brain reward system stimulates us to act in the interests of our own survival. Since dopamine creates a feeling of wellbeing, such as when we exercise or eat good food, the memory associates the two so that we will repeat the behaviour. Alcohol makes the brain reward system release more dopamine than normal, creating a pleasant euphoric sensation. However, the more alcohol drunk, the more the reward system is desensitised and the less dopamine is released. With time, greater volumes of alcohol are needed to cause intoxication and eventually to attain a state of physical and emotional normality – addiction has set in.In the clinical study, which is published in the scientific journal European Neuropsychopharmacology¸ the scientists examined for the first time if OSU6162 can reduce the craving for alcohol in people with alcohol dependence. Half the participants were treated with OSU6162 and half with placebo for a fortnight, after which both groups were exposed to different situations that could be assumed to elicit a craving for alcohol. The results show that the experimental group experienced less of a craving for alcohol after drinking one glass of an alcoholic beverage.“At the same time, the OSU6162 group reported not enjoying the first zip of alcohol as much as the placebo group,” says Dr Steensland. “One interesting secondary finding was that those with the poorest impulse control, that is those thought to be most at risk of relapse after a period of abstinence, were those who responded best to the OSU6162 treatment.”Adds to the understandingA study of rats published at the same time in the scientific journal Addiction Biology adds to the understanding of how OSU6162 works, as it shows that rats that voluntarily consumed alcohol for almost a year had lower levels of dopamine in their brain reward system than rats that had never drunk alcohol. However, when the “alcohol rats” were treated with OSU6162 it was found that the substance counteracted the low concentrations of dopamine in the brain reward system.“We therefore think that OSU6162 can reduce the alcohol craving in dependent people by returning the downregulated levels of dopamine in their brain reward system to normal,” says Dr Steensland.The rights to OSU6162 are owned by Nobel Laureate Arvid Carlsson, professor emeritus at the Sahlgrenska Academy, University of Gothenburg, whose team also invented the substance. Emeritus Professor Carlsson is also one of the co-authors of the clinical study. The research was financed with grants from several bodies, including the Swedish Brain Foundation, the Swedish Research Council, the Torsten Söderberg Foundation, Systembolaget’s alcohol research council and the Swedish Research Council for Health, Working Life and Welfare (FORTE).
An Atlas Air Boeing 747-400 freighter delivered 97 tonnes of staging and music equipment from Mexico City to Havana via Miami International airport.The Rolling Stones used the equipment at their free-to-attend concert on March 25 – the first open-air performance in the country by a British rock band, which was attended by an estimated 500,000 people.61 containers, some of which were delivered by sea, carried around 500 tonnes of additional equipment required to produce the show.Atlas Air has a long history of flying music equipment around the world, but because of the unusual destination, the airline explained that there were special visa, permitting and operational challenges to overcome. www.atlasair.com
More on the topicLevski and Petar Hubchev are expected to separate today or tomorrow, Blitz claims. The two sides are already negotiating the penalty of the coach, who has a valid contract with the club for another year.At his press conference at noon, the new owner of the “blues” Nasko Sirakov hinted at the upcoming coaching change, and announced that he would no longer rely on sports director Ivaylo Petkov.The parting with Hubchev comes against the background of the unsatisfactory performance of the team in the first semifinal of the Bulgarian Cup against Lokomotiv in Plovdiv. Last night the Blues lost 0: 2, which makes the team’s ranking for the final extremely difficult.
The rookie in the First League FC CSKA 1948 officially announced the transfer of Ivaylo Chochev. The national contract is for three years.There were extremely serious interests in the midfielder from several clubs, but he decided to continue his career under the leadership of former national team coach Krassimir Balakov. The 27-year-old, Ivaylo Chochev, has already accumulated many solid matches behind him, and the clubs so far in his career are Chavdar (Etropole), CSKA, Palermo and Pescara, reminded by his new team.For two years in CSKA Chochev played 50 games and scored 9 goals. He has the most matches with the Palermo shirt – nearly 120 in five years.It was with the team from the island of Sicily that Chochev played three seasons in Serie A, being in the heart of the team’s midfield in 75 games from one of the strongest championships in the world. Ivayli has recorded nearly 20 meetings with the team of the national team of Bulgaria.“Thanks to CSKA 1948 for giving me a hand in a difficult time for me. I can’t wait to get back on the field and play well. I missed football a lot during those months when I was injured. I join a good and ambitious team with a lot young motivated football players and quality experienced players. I am happy that everything is now official “, shared the new addition of FC CSKA 1948.Martin Kamburov: I could have moved to Levski“My wish was to stay in Beroe, but I was not guaranteed a starting place.”